UAB Advances in Brain Tumor Research Named Among Best of 2011

Congratulations to Markus Bredel, MD, PhD, of the UAB Department of Radiation Oncology. Dr. Bredel?s 2011 research on a type of brain tumor called Glioblastoma was named one of the top clinical research advances of the year by the American Society of Clinical Oncology.

Dr. Bredel?s findings originally appeared in the February 17, 2011, edition of the New England Journal of Medicine, the nation?s most distinguished peer-reviewed medical journal.

Bredel?s study was the first to implicate the deletion of a copy of a gene called NFKBIA as a contributing cause of glioblastoma. Mutations in NFKBIA, normally present on chromosome 14 in two copies (one each on the maternally and paternally inherited copies), have been shown to be present in a number of cancers including Hodgkin?s lymphoma, multiple myeloma, melanoma, breast, lung and colon cancer. This was also the first study to associate a deletion of NFKBIA with human cancer and is believed to be responsible for poor patient outcomes; but that could lead to better diagnosis and targeted treatments in the future.

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Source: http://cancer.uabmedicineblog.org/uab-advances-in-brain-tumor-research-named-among-best-of-2011/

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